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#bioinformatics (30 Repositories)

Ranked open-source repositories tagged with #bioinformatics, scored by pull request acceptance likelihood and maintainer engagement velocity.

Topic Avg Merge Rate

76.8%

Avg Review Latency

16.1h

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30 repositories tagged #bioinformatics

S TierTypeScript 5.5k

aipoch/open-science

The open-source AI research workbench for scientific research and agent workflows. Local-first, model-agnostic desktop app with extensible skills, MCP tools and connectors, Python/R execution and traceable artifacts for reproducible research on macOS, Windows and Linux.

77.3%
Merge Rate
12h
First Review
62%
1st-Timers
12
Maintainers
S TierPython 535

merenlab/anvio

An analysis and visualization platform for 'omics data

81.5%
Merge Rate
12h
First Review
75%
1st-Timers
8
Maintainers
A TierPython 102 2 GFIs

yuanzhw/AI-bioworkflow

Auditable bioinformatics workflow compiler: Catalog-bound planning, Workflow IR, and validated WDL 1.0.

100.0%
Merge Rate
<1h
First Review
100%
1st-Timers
1
Maintainers
S TierPython 229

helicalAI/helical

A framework for state-of-the-art pre-trained bio foundation models on genomics and transcriptomics modalities.

79.3%
Merge Rate
<1h
First Review
75%
1st-Timers
5
Maintainers
S TierPython 141

GuyTeichman/RNAlysis

Analyze your RNA sequencing data without writing a single line of code

93.0%
Merge Rate
3h
First Review
100%
1st-Timers
5
Maintainers
S TierRust 1.0k

xuzhougeng/wisp-science

Open-source, local-first desktop AI research workbench for scientific computing with Python/R, MCP bioinformatics tools, SSH/WSL/GPU runtimes, and OpenAI/Anthropic models.

85.0%
Merge Rate
-
First Review
75%
1st-Timers
7
Maintainers
A TierPython 113

MannLabs/alphadia

modular & open DIA search

53.6%
Merge Rate
<1h
First Review
50%
1st-Timers
5
Maintainers
A TierPython 321

Marsilea-viz/marsilea

Declarative creation of composable visualization for Python (Complex heatmap, Upset plot, Oncoprint and more~)

95.2%
Merge Rate
<1h
First Review
100%
1st-Timers
1
Maintainers
A TierPython 135

evo-design/proto-tools

A universal infrastructure layer for generative biology

88.9%
Merge Rate
-
First Review
100%
1st-Timers
4
Maintainers
A TierPython 1.2k

omicverse/omicverse

A python library for multi omics included bulk, single cell and spatial RNA-seq analysis.

93.1%
Merge Rate
8d
First Review
75%
1st-Timers
5
Maintainers
A TierRust 467

FelixKrueger/Bismark

A tool to map bisulfite converted sequence reads and determine cytosine methylation states

92.8%
Merge Rate
12h
First Review
100%
1st-Timers
2
Maintainers
A TierRust 218 4 GFIs

stjude-rust-labs/sprocket

A bioinformatics workflow engine built on top of the Workflow Description Language (WDL).

69.3%
Merge Rate
-
First Review
78%
1st-Timers
11
Maintainers
A TierPython 398

scverse/rapids-singlecell

rapids-singlecell: GPU-accelerated framework for scRNA analysis

72.4%
Merge Rate
<1h
First Review
0%
1st-Timers
4
Maintainers
A TierC 953

samtools/htslib

C library for high-throughput sequencing data formats

77.3%
Merge Rate
2h
First Review
67%
1st-Timers
8
Maintainers
A TierPython 1.9k 1 GFIs

galaxyproject/galaxy

Data intensive science for everyone.

39.1%
Merge Rate
-
First Review
33%
1st-Timers
39
Maintainers
A TierPython 1.1k

ClawBio/ClawBio

🦖 ClawBio - The first bioinformatics-native AI agent skill library. Local-first. Reproducible. Open. Free.

78.1%
Merge Rate
19h
First Review
86%
1st-Timers
9
Maintainers
A TierPython 488

aristoteleo/PantheonOS

A general, evolvable, and distributed agent framework & harness for data science.

91.8%
Merge Rate
4d
First Review
50%
1st-Timers
3
Maintainers
A TierRust 936

COMBINE-lab/salmon

🐟 🍣 🍱 Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment

66.1%
Merge Rate
-
First Review
100%
1st-Timers
2
Maintainers
A TierPython 772 1 GFIs

scverse/anndata

Annotated data.

82.1%
Merge Rate
4d
First Review
60%
1st-Timers
13
Maintainers
A TierPython 138

cogent3/cogent3

Comparative Genomics Toolkit 3

97.6%
Merge Rate
-
First Review
100%
1st-Timers
1
Maintainers
A TierGRGroovy 3.5k

nextflow-io/nextflow

A workflow language for data-driven computational pipelines

55.9%
Merge Rate
10h
First Review
33%
1st-Timers
27
Maintainers
A TierPython 347

scverse/pertpy

Single-cell perturbation analysis

81.4%
Merge Rate
-
First Review
75%
1st-Timers
5
Maintainers
A TierShell 1.9k

bioconda/bioconda-recipes

Conda recipes for the bioconda channel.

66.0%
Merge Rate
-
First Review
65%
1st-Timers
198
Maintainers
A TierPython 1.1k

hail-is/hail

Cloud-native genomic dataframes and batch computing

56.1%
Merge Rate
3h
First Review
40%
1st-Timers
10
Maintainers
A TierDODockerfile 225

StaPH-B/docker-builds

:package: :whale: Dockerfiles and documentation on tools for public health bioinformatics

52.2%
Merge Rate
3h
First Review
50%
1st-Timers
5
Maintainers
A TierJavaScript 1.5k

MultiQC/MultiQC

Aggregate results from bioinformatics analyses across many samples into a single report.

53.1%
Merge Rate
4h
First Review
33%
1st-Timers
12
Maintainers
A TierPython 1.2k

scikit-bio/scikit-bio

scikit-bio: a community-driven Python library for bioinformatics, providing versatile data structures, algorithms and educational resources.

68.3%
Merge Rate
15h
First Review
75%
1st-Timers
22
Maintainers
A TierJava 2.0k

broadinstitute/gatk

Official code repository for GATK versions 4 and up

66.7%
Merge Rate
-
First Review
80%
1st-Timers
11
Maintainers
A TierPython 932

tanghaibao/jcvi

Python library to facilitate genome assembly, annotation, and comparative genomics

90.0%
Merge Rate
5h
First Review
100%
1st-Timers
1
Maintainers
B TierNINim 339

brentp/somalier

fast sample-swap and relatedness checks on BAMs/CRAMs/VCFs/GVCFs... "like damn that is one smart wine guy"

100.0%
Merge Rate
2h
First Review
100%
1st-Timers
3
Maintainers
Best Bioinformatics Open Source Repositories & C-Rank™ | GetMerged